Freshteh Toghrol, Ph.D.

Founder and Director of the Microarray Research Laboratory

U.S. EPA, Office of Pesticide Programs

Biological & Economic Analysis Division (7503C)

Microarray Research Laboratory

701 Mapes Road, Fort Meade, MD 20755

 

E-mail: Toghrol.freshteh@epa.gov

Phone: (410) 305-2755

Fax: (410) 305-3091

EDUCATION

Doctor of Philosophy in Biochemistry, University of Southampton, Southampton, England

PROFESSIONAL EXPERIENCE

2002 to present  Senior Science Advisor, Director. Microarray Research Laboratory

United States Environmental Protection Agency, Fort Meade, Maryland

1994 to 2002    Chemist. Office of Pesticide Programs / Biopesticides and Pollution Prevention

United States Environmental Protection Agency, Arlington, Virginia

1988 to 1994    Chemist. Office of Pesticide Programs / Health Effect Division

United States Environmental Protection Agency, Arlington, Virginia

1987 to 1988    Researcher. National Institutes of Child Development

National Institutes of Health, Bethesda, Maryland

SELECTED PUBLICATIONS

Textbooks

An Introduction to Biochemistry, Tehran University Press, 1973, Second Edition, 1977 (600 pages translated/edited).

Peer-Reviewed Articles

1. C. Nde, F. Toghrol, H. Jang and W. Bentley (2010), "Toxicogenomic Response of Mycobacterium bovis BCG to Peracetic acid" and "Comparative Analysis of the Mycobabacterium bovis BCG Response to Three Oxidative Disinfectants," Applied Microbiology and Biotechnology
   http://dx.doi.org/10.1007/s00253-010-2931-6
2. H. Jang, C. Nde, F. Toghrol, and W. Bentley (2009). Microarray Analysis of Mycobacterium bovis BCG Revealed Induction of Iron Acquistion Related Genes in Response to Hydrogen peroxide. Environmental Science and Technology (ES&T). Published November 7th, 2009.
   http://pubs.acs.org/articlesonrequest/AOR-pzXk3aiNfSiUfKsryzuU
3. H. Jang, C. Nde, F. Toghrol, and W. Bentley (2009) “Global Transcriptome Analysis of the Mycobacterium bovis BCG Response to Sodium hypochlorite,” Applied Microbiology and Biotechnology (AMB) Published on September 27th, 2009.
   http://www.springerlink.com/openurl.asp?genre=article&id=doi:10.1007/s00253-009-2208-0
4. C. Nde, H. Jang, F. Toghrol, and W. Bentley (2009). Global Transcriptomic Response of Pseudomonas aeruginosa to Chlorhexidine diacetate. Environmental Science and Technology Journal. Published on September 10th, 2009.
   http://pubs.acs.org/doi/pdfplus/10.1021/es9015475
5. C. Nde, H. Jang, F. Toghrol, and W. Bentley (2008).Toxicogenomic Effects of Ortho-phenyl phenol (OPP) on Pseudomonas aeruginosa. BMC Genomics. Published on Oct. 10 2008.
   http://www.biomedcentral.com/1471-2164/9/473
6. H. Jang, C. Nde, F. Toghrol, and W. Bentley (2008).Toxicogenomic Effects of Ortho-phenyl phenol (OPP) on Staphylococcus aureus. BMC Genomics. Published on Sep. 15 2008.
   http://www.biomedcentral.com/1471-2164/9/411
7. H. Jang,  W. Chang, F. Toghrol, and W. Bentley (2007).  Microarray Analysis of Toxicogenomic Effects of  Triclosan on Staphylococcus aureus.  Applied Microbiology & Biotechnology. Published Jan 22nd 2008. http://dx.doi.org/10.1007/s00253-008-1349-x
8. W. Chang,   F. Toghrol, and W. Bentley (2007). Toxicogenomic  Response to Chlorination Includes Induction of Major Virulence Genes in Staphylococcus aureus.  Environmental Science and Technology. Published Nov 1st 2007. http://pubs.acs.org/cgi-bin/abstract.cgi/esthag/asap/abs/es070929k.html
9. D. Small, W. Chang, F. Toghrol, and W. Bentley (2007). Comparative global transcription analysis of sodium hypochlorite, peracetic acid, and hydrogen peroxide on Pseudomonas aeruginosa. Applied Microbiology & Biotechnology, 2007 Oct; 76(5):1093-105
10. D. Small, W. Chang, F. Toghrol, and W. Bentley (2007). Toxicogenomic Analysis of Sodium hypochlorite Antimicrobial Mechanisms in Pseudomonas aeruginosa.  Applied Microbiology & Biotechnology, 2007 Feb; 74(1):176-85  
11. W. Chang, F. Toghrol, and W. Bentley (2006). Toxicogenomic response of Staphylococcus aureus to peracetic acid. Environmental Science and Technology 40(16) 5124-5131.
12. W. Chang, D. Small, F. Toghrol, and W. Bentley (2006). Global transcriptome analysis of Staphylococcus aureus response to hydrogen peroxide. Journal of Bacteriology 188(4) 1648-1659.
13. W. Chang, D. Small, F. Toghrol, and W. Bentley (2005) Microarray analysis of Pseudomonas aeruginosa reveals induction of pyocin genes in response to hydrogen peroxide. BMC Genomics 6(1) 115
14. W. Chang, D. Small, F. Toghrol, and W. Bentley (2005). Microarray analysis of toxicogenomic effects of peracetic acid on Pseudomonas aeruginosa. Environmental Science and Technology 39(15) 5893-5899.

Presentations

1. Chantal W. Nde, Hyeung-Jin Jang, Freshteh Toghrol and William E. Bentley (2010). Comparative Transcriptomics of the Response of Mycobacterium bovis BCG to sodium hypochlorite, hydrogen peroxide and peracetic acid. A Poster Presentation at the 50th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Boston, MA, held September 12th – 15th, 2010.
2. H. Jang, C. Nde, F. Toghrol, and W. Bentley (2009). Toxicogenomic Response of Mycobacterium bovis BCG to Hydrogen peroxide. A Poster Presentation at the Toxicogenomics Integrated Environmental Science (TIES) meeting held September 20-23, 2009 in Seoul, South Korea.
3. C. Nde, H. Jang, F. Toghrol, and W. Bentley (2009). Toxicogenomic Response of Mycobacterium bovis BCG to Peracetic acid. A Poster Presentation at the 49th Annual Interscience Conference on Anti-microbial Agents and Chemotherapy (ICAAC) held September 12th, 2009 in San Francisco, California.
4. H. Jang, C. Nde, F. Toghrol, and W. Bentley (2009). Global Transcriptomic Response of Mycobacterium bovis BCG to Sodium hypochlorite: Quantitative ATP Rapid Screening Method for Mycobacterial Cell Viability, a Poster Presentation at the 10th General Meeting of American Society for Microbiology Conference in Philadelphia held May 17th – May 21st, 2009. 
5. C. Nde, F. Toghrol, and W. Bentley (2009). Toxicogenomic Response of Pseudomonas aeruginosa to Chlorhexidine diacetate. a Poster Presentation at the 10th Annual General Meeting of American Society for Microbiology Conference in Philadelphia held May 17th – May 21st, 2009.
6. C. Nde, F. Toghrol, and W. Bentley (2009). Summary of Global Toxicogenomic Effects of Disinfectants on Pathogenic Bacteria Impacting Human Health, a Poster Presentation at the 10th Anniversary Celebration of the Environmental Science Center (ESC) held April 14th, 2009.
7. C. Nde, F. Toghrol, and W. Bentley (2009). On the Forefront : “New Technologies,” Microarray Technology used by MARL was illustrated and described. a Poster Presentation at the 10th Anniversary Celebration of the Environmental Science Center (ESC) held April 14th, 2009.
8. C. Nde, H. Jang, F. Toghrol, and W. Bentley (2008). Global Transcriptome Analysis of Pseudomonas aeruginosa Response to Ortho-phenyl phenol: A 15 minute Slide presentation at the 46th Annual Meeting of the Infectious Diseases Society of America (IDSA), and the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC): a Joint meeting of the American Society for Microbiology (ASM) and IDSA, held October 25-28, 2008 in Washington , D.C .
9. H. Jang, C. Nde, F. Toghrol, and W. Bentley (2008). Toxicogenomic response of Staphylococcus aureus to Ortho-phenyl phenol: A Poster presentation at the 46th Annual meeting of the Infectious Diseases Society of America (IDSA), and the 48th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC): a Joint meeting of the American Society for Microbiology (ASM) and IDSA, held October 25-28, 2008 in Washington, DC.
10. H. Jang, F. Toghrol, and W. Bentley (2008). Toxicogenomic Response of Staphylococcus aureus to Triclosan Stress at the 2008 American Society of Biochemistry and Molecular Biology (ASBMB) Annual Meeting, held April 5- 9 in San Diego, CA.
11. W. Chang, F. Toghrol, and W. Bentley (2006) Genome-wide transcriptional response of Staphylococcus aureus to hypochlorite-induced oxidative stress. American Institute of Chemical Engineers Annual Meeting, San Francisco CA.
12. W. Chang, F. Toghrol, and W. Bentley (2006) Genome-wide transcriptional analysis of Staphylococcus aureus response to oxidative antimicrobials: hydrogen peroxide and peracetic acid. American Society for Microbiology General Meeting, Orlando FL.
13. W. Chang, D. Small, F. Toghrol, and W. Bentley (2006) Whole-Genome transcriptional analysis of hydrogen peroxide-induced oxidative stress in Staphylococcus aureus, a human pathogen. EPA Science Forum, Washington DC.
14. D. Small, W. Chang, F. Toghrol, and W. Bentley (2006) Comparative global transcriptome analysis of sodium hypochlorite, peracetic acid, and hydrogen peroxide on Pseudomonas aeruginosa. EPA Science Forum, Washington DC.
15. W. Chang, D. Small, F. Toghrol, and W. Bentley (2005) Microarray analysis of toxicogenomic effects of hydrogen peroxide, peracetic acid, and sodium hypochlorite on Staphylococcus aureus. EPA Science Forum, Washington DC.
16. W. Chang, D. Small, F. Toghrol, and W. Bentley (2004) Transcriptome analysis of Pseudomonas aeruginosa response to hydrogen peroxide. University of Maryland Biotechnology Research Review Day, College Park, MD.
17. D. Small, W. Chang, F. Toghrol, and W. Bentley (2004) Toxicogenomic effects of sodium hypochlorite on Pseudomonas aeruginosa. University of Maryland Biotechnology Research Review Day, College Park, MD.
18. W. Chang, D. Small, F. Toghrol, and W. Bentley (2004) Toxicogenomic effects of peracetic acid and sodium hypochlorite on Pseudomonas aeruginosa. EPA Science Forum, Washington DC.